The Santuario de Nuestra Señora de Guadalupe was completed  in the early 18th century, and is a good example of Pueblan Baroque, with stone-based ornamentation, tile, brick and mortar. The towers and domes show the wealth of that style. The facade is notable for tile panels that show the four apparitions of the Virgin of Guadalupe and other Marian symbols. The interior of the Our Lady of Guadalupe Sanctuary is simple, transformed to the neoclassical style that prevailed in the second half of the 19th century. In its adjoining chapel dedicated to Our Lady of Sorrows, the plaster grotesques have been preserved intact (whimsical adornments with bugs, insects, chimeras and foliage, so named because they imitate those found in the caves formed by the excavated Roman ruins) in which stand out angels and other typical forms of Baroque exuberance.

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